Priyakshi Kalita-de Croft
My research objectives are aimed towards understanding and developing therapeutic interventions for breast cancer metastases. I am interested in understanding the influence of the tissue microenvironment (TME) in metastases, which is known to play a role in this process. Currently, I am investigating the role of brain TME in establishing brain metastatic tumours from the breast. For this I am looking at the function of different deregulated proteins in brain metastases. I use intra-cranial, intra-cardiac, intra-carotid preclinical models along with molecular biology, genomic and proteomic tools for my studies. I would like to expand my future studies to other most commonly metastasised organs for breast cancer such as bone and lungs. Furthermore, I would like to develop patient derived xenograft models to better understand the clinical behaviour of tumours and develop targeted therapies consequently. My long-term goal is to develop a streamlined preclinical programme which can be used for translational breast cancer and metastases research.
Abstracts this author is presenting: