Thursday, 8th February 30th Lorne Cancer Conference 2018

Welcome David Vaux

• Roles of GSK-3 in cancer suppression as determined in tissue-specific mouse models. - Jim Woodgett
• Crosstalk between oncogenic signalling pathways reprograms lipid metabolism in cancer - Kristin Brown
• Hhex induces promyelocyte self-renewal and cooperates with growth factor independence to cause myeloid leukemia in mice. - Matthew P McCormack
• The smac-mimetic birinapant as a targeted therapy for triple-negative breast cancers - Najoua Lalaoui
• RNA-based cancer therapeutics – are we there yet? - Peter Leedman

• Involvement of the cytoskeletal regulator AFAP1L1 in sarcoma invasion and migration - Evan Ingley
• A Genome-wide RNAi Screen Identifies Synthetic Lethality of CX-5461 with TOP1 inhibition in Ovarian Cancer - Shunfei Yan
• Blood brothers: Exosomal DNA and circulating tumour DNA as complementary tools for disease monitoring in breast cancer - Kate Meehan
• Combined treatment with CDK4/6 and PI3Kα inhibitors is immunogenic and effective against triple-negative breast cancer   - Zhi Ling Teo
• A novel metabolic regulatory mechanism of leukaemia stem cells in acute myeloid leukaemia - Patrick Connerty
• The identification of rare variants in Tasmanian prostate cancer pedigrees using whole-genome sequencing - Kelsie Raspin
• The pro-survival protein Mcl-1 as a therapeutic target in mantle cell lymphoma   - Michael A Dengler
• Inhibition of the protein arginine methyltransferase PRMT5 overcomes resistance to CDK4-inhibition in melanoma - Shatha AbuHammad
• Coordination Of DNA Repair Is Critical For P53-Mediated Tumour Suppression - Ana Janic
• The Mutational Landscape of Familial Breast Cancers - Peter Simpson
• Insights from the Australian Melanoma Genome Project - Graham Mann

Flash Talk Posters

#101-#110

• Deciphering the combinatorial complexity of Wnt-Frizzled interactions - Mark Agostino
• Structural basis of integrin antagonism by netrin-like domain-containing proteins - Mark Agostino
• Knowledge-based scoring functions for predicting carbohydrate-protein interactions - Mark Agostino
•   RAGE-Seq: A method for massively parallel profiling of transcriptomes and antigen receptors of B- and T-Cells at the single-cell level using long-read and short-read sequencing. - Ghamdan Al-Eryani
• Exploring the role of hERG channels in breast cancers, using novel urea compounds that modulate hERG function - Sara Al-Rawi
• Molecular mechanisms underpinning resistance to endocrine therapy and CDK4/6 inhibitors in breast cancer - Sarah Alexandrou
• Stat3 inhibition in the tumour microenvironment restricts gastrointestinal tumour growth - Mariah MA Alorro
• Activation of the orphan receptor GPR55 by lysophosphatidylinositol promotes metastasis in triple-negative breast cancer - Clara Andradas Arias
• Drug discovery and development using the ACRF Drug Discovery Centre - Greg M Arndt
• High-throughput 3D bioprinting of embedded multicellular cancer spheroids: Novel approach for precision medicine - Lakmali Atapattu
• A role for lipid raft-associated proteins in hematopoiesis and leukemogenesis - Alexander Azimpour
• Anti-metastasis therapy via nanoparticle mediated drug delivery - Stefan Bader
• Aptahistochemistry to detect co-localised surface stemness markers in colorectal cancer xenografts and identify putative cancer stem cells - Michelle Bauer
• Rational targeting of MLL-driven acute myeloid leukaemia with novel CDK9 and MEK/FLT3 combination therapy - Stefan Bjelosevic
• DiCAM (DiChloroAcetate in Myeloma): a trial of the glycolytic phenotype inhibitor dichloroacetate for the treatment of multiple myeloma patients in partial remission - Anneke C Blackburn
• Interferons and personalized immunotherapy in breast cancer - Natasha K Brockwell
• Therapeutic targeting and disease monitoring in CNTRL-FGFR1 driven leukaemia - Lauren M Brown
• Links between DNA replication stress and telomere extension in cancer cells - Tracy M Bryan
• Investigating the metabolic reprogramming resulting from a single knock-in PIK3CA^H1047R mutation in cancer - Sabrina Caiazzo
• Loss of p53 alters the segregation of DNA into cancer micronuclei - Elizabeth Caldon
• GLUT6 and endometrial cancer – an inflammatory link - Beth Caruana
• Reactivation of RAS/ERK signalling facilitates PI3K/AKT/mTORC1-dependent cellular senescence evasion - Keefe T Chan
• Fragment size analysis of plasma cell-free DNA boosts non-invasive cancer genomics - Dineika Chandrananda
• Therapeutic targeting of OLIG2 in high-grade glioma - Charlotte Chen
• FcγR-mediated responses to therapeutic antibodies by Nurse Like cells are PI3Kδ-dependent in CLL patients - Yu-Chen Enya Chen
• A switch in mechanism of action prevents doxorubicin-mediated cardiotoxicity - Alison Cheong
• Investigating the effect of combination therapy on cetuximab inhibition of epidermal growth factor receptor signalling combined with dynamin inhibition in head and neck cancer squamous cell carcinoma - Hui Yi Chew
• The relevance of SMAD4 expression in regulation of breast cancer metastasis - Lap Hing Chi
• Mechanisms of resistance of BRAF^V600E colorectal cancer to BRAF inhibitors - Fiona Chionh
• Targeting the Thioredoxin System to Overcome Hypoxia-Induced and Acquired Imatinib Resistance in Chronic Myeloid Leukaemia - Erin Clapper
• Electron microscopy of human telomerase - Scott Cohen
• Molecular imaging of B anthracis protective antigen targeting endogenous mouse squamous cell carcinoma - Theo Crawford
• High-resolution intravital imaging of mammary gland morphogenesis - Caleb A Dawson
• Determining the role of PIK3CA mutation in DNA damage and repair - Francesc d'Assis de las Heras Vila
• Mechanism of GP130 activation and regulation of its downstream signalling - Farhad Dehkhoda
• PAR3 loss predisposes mice to developing acute myeloid leukaemia via dysregulation of the Hippo pathway - Alysha Dew
• Mammary Tumor Associated RNAs (MaTARs) as drivers of tumor cell growth and metastasis - Sarah D Diermeier
• Interrogating the effects of Keap1 inactivation on the metabolism of Kras-mutant lung adenocarcinomas - Sheryl Ding
• Targeting Protein Tyrosine Phosphatases(PTPs) to enhance the T cells cancer immunotherapy - Xin Du
• A phase I study of intralesional Bacillus Calmette-Guerin (BCG) followed by ipilimumab therapy in patients with advanced metastatic melanoma - Jessica Duarte
• Myoepithelial protease inhibitors as regulators of breast cancer cell escape - Hendrika M Duivenvoorden
• Signalling via the IL-3/IL-3R axis promotes breast cancer progression via unsuspected paracrine effects - Camille DULUC
• Agonist immunotherapy restores dysfunctional T cells following MEK inhibition and improves therapeutic efficacy. - Sathana Dushyanthen
• IL-33 signalling: An oncogenic or a tumour suppressor pathway in gastro-intestinal cancers? - Moritz F Eissmann
• Illuminating the role of caspase 3 deletions in human colorectal cancer - Meg Elliott
• Predicting treatment outcomes for colorectal cancer patients using tumour-derived organoids - Rebekah M Engel
• Targeting Jak Kinases For The Treatment Of Gastrointestinal Cancers - Nima Etemadi
• Control of cell competition by cell shape regulators in tissue development and cancer   - Natasha Fahey Lozano
• An in vitro drug sensitivity testing platform for identifying personalised drug treatments for high risk childhood cancer patients - Tim W Failes
• Brm Regulates Cell Cycle and Photolesion Development in Keratinocytes in Response to Ultraviolet Radiation - Andrew W Farrell
• Itraconazole as a novel treatment for pancreatic cancer - Danielle Froio
• Deciphering the mechanisms of suppression of SLC7A11 by wild type and mutant p53 - Kenji Fujihara
• Cisplatin resistance in lung adenocarcinoma: a live-imaging approach - Alvaro Gonzalez Rajal
• Defining functional drivers of oesophageal tumourigenesis   - Jovana Gotovac
• Chromatin remodelling activity of G-quadruplex stabilising ligands - Melanie Grigg
• The complex roles of STAT3 in Myc-driven tumourigenesis - Aleks Guanizo
• Rab27a promotes melanoma cell invasion and metastasis via the regulation of exosomes - Dajiang Guo
• Microphthalmia-associated transcription factor regulates dynamic melanoma heterogeneity - Nikolas K Haass
• Novel therapeutic strategies for glioblastoma treatment - Emma M. Hays
• The delivery of doxorubicin to cancer cells using a DNA aptamer targeting EpCAM - Justin L Henri
• Exploring autophagy and the time dependent changes on the sensitivity of breast cancer cells to Tamoxifen under hypoxic conditions   - Alana Higgins
• Targeting microtubule dynamics with eribulin as a potential therapeutic strategy in the treatment of fallopian-tube/ovarian carcinosarcoma - Gwo Yaw Ho
• Oncogenic MYD88 mutations, the dark side of B cell development - Keisuke Horikawa
• Modelling the development of Barrett’s oesophagus and oesophageal adenocarcinoma - Elhadi Iich
• Investigating the role of heparanase in breast cancer progression using the PyMT-MMTV mouse model - Krish Jayatilleke
• Combining HDAC and MAPK inhibitors as a therapeutic strategy to promote differentiation of colorectal cancer - Laura J Jenkins
• Targeting YB-1 controls drug response via distinct mechanisms in malignant pleural mesothelioma - Thomas G Johnson
• New Treatments for High-Risk Acute Lymphoblastic Leukaemia in Children - Conner Jones
• Cyto-Mine: An integrated picodroplet system for single-cell analysis and monoclonality assurance - Dimitris Josephides
• DNA barcoding demonstrates that the immune system and immunotherapies can regulate metastatic breast cancer growth at the clonal level - Simon Junankar
• Overcoming sorafenib resistance in hepatocellular carcinoma with RNA-based therapeutics - Tasnuva Kabir
• Proteomic analysis of the mouse brain stromal microenvironment: a milieu intérieur of metabolic reprogramming - Priyakshi Kalita-de Croft
• PEGylation strategies for optimizing the lymphatic exposure and activity of interferon alpha2 after subcutaneous administration - Lisa M Kaminskas
• Deciphering the extracellular matrix code underlying therapeutic radiation resistance in human prostate cancer. - Simon P Keam
• ALLOCATE - sorting ovarian cancer patients into treatment categories based on molecular profiling - Olga Kondrashova
• Unravelling the role of g-quadruplex and paraspeckle formation in breast cancer - Amy L Kretzmann
•   A GENETICALLY ENGINEERED MOUSE MODEL OF FALLOPIAN TUBE DERIVED OVARIAN CARCINOSARCOMA - Elizabeth Kyran
• Discovery of a novel DHODH inhibitor capable of increasing p53 synthesis and enhancing tumour cell killing by p53 degradation blockage - Marcus JGW Ladds
• Andy’s Algorithms: new automated digital image analysis pipelines for FIJI - Andrew M.K Law
• A preclinical platform for evaluating targeted therapy and immunotherapy combinations in BRAF^V600E melanoma - Emily J Lelliott
• Human NAT1 plays a role in triple negative breast cancer cell invasion by transcriptional regulation of MMPs - Pengcheng Li
• Driving PARP inhibitor resistance in high-grade serous ovarian cancer patient derived xenografts - Elizabeth Lieschke
• Translocation breakpoints preferentially occur in euchromatin and acrocentric chromosomes - Cheng-Yu Lin
• Novel candidates in the regulation of lymphangiogenesis and lymphatic vessel remodelling - Ruofei Liu
• PTPN2-deficiency improves adoptive CAR T cell immunotherapy - Kun-Hui Lu
• Novel combination therapies with the RNA polymerase I inhibitor CX-5461 significantly improve efficacy in multiple myeloma - Kylee Maclachlan